Paulina Cegla
Greater Poland Cancer Centre, Poland
Title: Infl uence of 18F-FDG-PET/CT on the treatment planning in patients with cervical cancer
Biography
Biography: Paulina Cegla
Abstract
In female gynecologic cancer, positron emission tomography in combination with computed tomography (PET/CT) is useful in
patients with locally advanced cervical cancer prior to radical combination of therapy. Th is study is more accurate than other
imaging methods, because it allows to assess local lymph nodes and the presence of distant metastases during one study. Some
studies were done where author suggest that 18F-FDG-PET/CT study can change management of patients treatment due to
identifi cation of para-aortic lymph node or distant metastasis in advanced stages. Aim of this study was to evaluate the usefulness
of 18F-FDG-PET/CT on the treatment in cervical cancer patients. A retrospective analysis was performed on 200 previously
untreated patients with a histologically confi rmed cervical cancer, admitted to the Department of Radiotherapy and Gynecological
Oncology at the Greater Poland Cancer Center between May 2009 and May 2013 for treatment planning. PET scans were acquired
on Gemini TF PET/CT scanner 60min aft er IV injection of 2-[(18)F]-fl uoro-2-deoxy-D-glucose with the mean activity of 364±75
MBq, with the area being examined extending from the calvaria, to half way down the thigh. Th e reconstructed PET images were
evaluated on a dedicated workstation. Tumour volumes were calculated using semiautomatic segmentation method; for metabolic
activity SUVmax was used. 18F-FDG-PET/CT has a signifi cant infl uence in assessing the severity of the disease, especially in the
evaluation of lymph nodes outside the pelvis and in the selection of the appropriate method of radiotherapy. PET-CT is a powerful
tool in the treatment planning of cervical cancer with the regard to the optimal choice of therapeutic procedure (based on FDGPET/
CT scan 1/3 of patients required radical change of treatment procedure).